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Bone marrow aspiration and biopsy : The removal of bone marrow, blood, and a small piece of bone by inserting a hollow needle into the hipbone or breastbone

Additionally, our immunohistochemistry studies showed a significant reduction in CD45 staining across all TLR KO mouse models, further supporting a decrease in pro-tumor inflammatory TME of these mice ( Supplementary Figure S3F, G )

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If p53 is mutated, unable to function as a transcriptional regulator, and unable to mediate apoptosis, cells can continue to divide without DNA repair, chromosomal damage may occur and magnify with each cell division, and neoplasia can ensue (see Figure 2)